desmopressin, imipramine, and oxybutynin in the treatment of primary nocturnal enuresis: a randomized clinical trial
نویسندگان
چکیده
conclusions there is no significant difference between monotherapy with desmopressin, imipramine or oxybutynin in children with enuresis. however, oxybutynin showed a higher response rate and a lower relapse rate compared to other medications. more clinical trials with a larger sample size are needed to clarify these uncertainties. results children in the oxybutynin group showed a slightly higher response rate (71.0% success) and a lower relapse rate (31.8%), while in the desmopressin group the response and relapse rates were 63.3% and 57.9%, respectively, and in the imipramine group 61.3% and 63.2%, respectively. however, the difference between the 3 groups in terms of response (p = 0.701) and relapse rates (p = 0.095) was not statistically significant. background nocturnal enuresis is the most common pediatric urologic problem in outpatient clinics. objectives to assess the effect of various monotherapies, and comparing the effects of desmopressin, imipramine, and oxybutynin in children with enuresis, as well as the influence of socioeconomic and cultural factors of their families on the response and relapse rates. patients and methods the study was a randomized clinical trial conducted on 92 children aged 5 - 14 years, referred to the pediatric clinic of semnan university hospital in semnan, iran. children with primary nocturnal enuresis were randomly allocated to three different treatment groups: desmopressin (n = 30), imipramine (n = 31), and oxybutynin (n = 31) all for 6 weeks. the socioeconomic and demographic characteristics of all participants were recorded. the number of wet nights per week was noted at the end of the 6-week-trial, and children were followed up to three months for relapse.
منابع مشابه
Desmopressin, Imipramine, and Oxybutynin in the Treatment of Primary Nocturnal Enuresis: A Randomized Clinical Trial
BACKGROUND Nocturnal enuresis is the most common pediatric urologic problem in outpatient clinics. OBJECTIVES To assess the effect of various monotherapies, and comparing the effects of desmopressin, imipramine, and oxybutynin in children with enuresis, as well as the influence of socioeconomic and cultural factors of their families on the response and relapse rates. PATIENTS AND METHODS Th...
متن کاملCombined Treatment with Oxybutynin and Imipramine in Enuresis
Background: Primary nocturnal enuresis is a common disorder that often leads to considerable distress in affected children and their family. In many countries pharmacologic therapy is preferred to non-pharmacologic behavioral and conditional alarm therapy. Imipramine, oxybutynin, and desmopressin have been used for enuresis with various efficacies. The aim of the present study was to compare th...
متن کاملComparison of combined treatment with desmopressin plus oxybutynin and desmopressin plus tolterodine in treatment of children with primary nocturnal enuresis
INTRODUCTION Nocturnal enuresis (enuresis) is one of the most common developmental problems of childhood, which has often a familial basis, causes mental and psychological damage to the child and disrupts family solace. OBJECTIVES In this study, we compared therapeutic effects of combination therapy of desmopressin plus oxybutynin with desmopressin plus tolterodine, in the treatment of childr...
متن کاملDesmopressin in nocturnal enuresis.
The response of desamino-D-arginine vasopressin (DDAVP) was investigated in 32 enuretic children in a double-blind clinical study. The 15 children treated with DDAVP showed a significant reduction in the incidence of bed wetting--from 18.7 +/- 6.5 to 6.5 +/- 9.2 wet nights per 30 days. In 6 children bed wetting stopped entirely, in 6 there was a satisfactory response, and in 3 the response was ...
متن کاملCombined Treatment with Oxybutynin and Imipramine in Enuresis
Background: Primary nocturnal enuresis is a common disorder that often leads to considerable distress in affected children and their family. In many countries pharmacologic therapy is preferred to non-pharmacologic behavioral and conditional alarm therapy. Imipramine, oxybutynin, and desmopressin have been used for enuresis with various efficacies. The aim of the present study was to compare th...
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عنوان ژورنال:
iranian red crescent medical journalجلد ۱۷، شماره ۷، صفحات ۰-۰
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